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Because the transition itself carries real risks

The agency notes that semaglutide salt forms, including semaglutide sodium and semaglutide acetate, are not equivalent to the active ingredient used in FDA-approved drugs and are not authorized for compounding

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Hence, in 2022, glucose-lowering efficacy and proven cardiovascular effects were important for the strong positioning of semaglutide, dulaglutide and tirzepatide in guidelines on the management of hyperglycaemia in type 2 diabetes [33], and a similar strong positioning of incretin therapy was seen in guidelines on primary care [39]